Scientific Publications

Peer-Reviewed Journal Publications:

2021

Haplotype-Aware Inference Of Human Chromosome Abnormalities

PNAS, 2021.  https://www.pnas.org/content/118/46/e2109307118

Human Pre-Implantation Embryos Are Permissive to SARS-CoV-2 Entry

bioRxiv, 2021. (Under Review) https://www.biorxiv.org/content/10.1101/2021.01.21.427501v1

Using Outcome Data From One Thousand Mosaic Embryo Transfers To Formulate An Embryo Ranking System For Clinical Use

Fertility and Sterility, 2021. https://www.fertstert.org/article/S0015-0282(20)32716-3/fulltext

2020

Preimplantation Genetic Testing For Chromosomal Abnormalities: Aneuploidy, Mosaicism, And Structural Rearrangements

Genes, 2020. https://www.mdpi.com/2073-4425/11/6/602

2019

Estimating Demand For Germline Genome Editing: An In Vitro Fertilization Clinic Perspective

The CRISPR Journal, 2019. https://www.liebertpub.com/doi/abs/10.1089/crispr.2019.0044

Births From Embryos With Highly Elevated Levels Of Mitochondrial DNA

Reproductive Biomedicine Online, 2019. https://www.rbmojournal.com/article/S1472-6483(19)30373-6/abstract

One  Hundred Mosaic Embryos Transferred Prospectively In A Single Clinic:  Exploring When And Why They Result In Healthy Pregnancies

Fertility and Sterility, 2019.   https://www.fertstert.org/article/S0015-0282(18)32141-1/fulltext

Assessment Of Aneuploidy Concordance Between Clinical Trophectoderm Biopsy And Blastocyst

Human Reproduction, 2019.   https://doi.org/10.1093/humrep/dey327

2017

Is MtDNA Quantitation Of Trophectoderm Cells Predictive Of Blastocyst Development Competence And Outcome In Clinical IVF?

Journal of Assisted Reproductive Medicine, 2017.  https://link.springer.com/article/10.1007%2Fs10815-017-1072-6

Accurate Quantitation Of Mitochondrial DNA Reveals Uniform Levels In Human Blastocysts Irrespective Of Ploidy, Age, Or Implantation Potential.

Fertility and Sterility, 2017. Selected as a ‘Seminal Contribution’.  http://www.fertstert.org/article/S0015-0282(16)62848-0/fulltext          

Commentary by Dr. Richard Scott:   http://www.fertstert.org/article/S0015-0282(16)63024-8/fulltext

Video highlight of the study: https://youtu.be/ELBnPMZaX5E

Abstract Publications and Presentations:

2021

Making Sense Of Mosaicism In PGT-A

World Congress on Controversies in Preconception, Preimplantation and Prenatal Genetic Diagnosis (CoGEN), Online, 2021

Assessing The Embryo’s DNA For Aneuploidy

Howard and Georgeanna Jones Symposium on Assisted Reproductive Technology

American Society of Reproductive Medicine (ASRM), Baltimore, USA 2021

The Embryo As A Source Of Diagnostic Material

American Society of Reproductive Medicine (ASRM), Baltimore, USA 2021

The Effect Of Culturing Conditions And Embryo Morphology On The Performance Of Non-Invasive PGT-A

American Society of Reproductive Medicine (ASRM), Baltimore, USA

Presented By Our Collaborators

Embryo Mosaicism – Reproductive Outcome

Preimplantation Genetic Diagnosis International Society (PGDIS) Live Webinar, June 2021

See the recorded webinar here.

Obstetric Outcomes Of Mosaic Embryo Transfers

Canadian Fertility & Andrology Society (CFAS) Webinar, June 2021

Selecting The Best Mosaic Embryo For Transfer

International IVF Initiative (I3) Webinar, January 2021

See the recorded webinar here.

2020

Human Pre-Implantation Embryos Are Permissive to SARS-CoV-2 Entry (Late-Breaking Abstract)

American Society of Reproductive Medicine (ASRM), Virtual Meeting, 2020     See full abstract

New Insights From One Thousand Mosaic Embryo Transfers: Features of Mosaicism Dictating Rates of Implantation, Spontaneous Abortion, and Neonate Health (Prize Paper Session)

American Society of Reproductive Medicine (ASRM), Virtual Meeting, 2020    See full abstract

Assessment Of Cell-Free DNA From Embryo Spent Media And Its Effect On Non-Invasive PGT-A Concordance To Conventional PGT-A And Calculated Copy Number Noise

American Society of Reproductive Medicine (ASRM), Virtual Meeting, 2020     See full abstract

Presented By Our Collaborators

RNA For PGT-A And Identification Of New Biomarkers Of Clinical Outcome In IVF

American Society of Reproductive Medicine (ASRM), Virtual Meeting, 2020     See full abstract

Presented By Our Collaborators

2019

Blastocysts With Disproportionally High Mitochondrial DNA Copy Number Can Result In Healthy Babies

The Foundation for Reproductive Medicine (FRM), New York, USA 2019       See full abstract

Mosaic Embryos – A Comprehensive And Powered Analysis Of their Clinical Outcomes

American Society of Reproductive Medicine (ASRM), Philadelphia, USA 2019    See abstract here

Mosaic Embryo Transfers – A Compiled Analysis Of Published Data

Preimplantation Genetic Diagnosis International Society (PGDIS), Geneva, Switzerland 2019    See full abstract

CRISPR Gene  Editing And Ramifications (Keynote Address)

Hamilton Thorne Clinical Manipulation Workshop, Fort Lauderdale, USA 2019   See Program

2018

100 Mosaic Embryo Transfers In A Single Clinic: What We Have Learned

American Society of Reproductive Medicine (ASRM), Denver, USA 2018     See full abstract

80 Mosaic Embryo Transfers In A Single Clinic With In-House PGT-A: What We Have Learned

Preimplantation Genetic Diagnosis International Society (PGDIS), Bangkok, Thailand 2018    See full abstract

Aneuploidy Concordance Between Trophectoderm And Inner Cell Mass By Next-Generation Sequencing In 100 Blastocysts

Preimplantation Genetic Diagnosis International Society (PGDIS), Bangkok, Thailand 2018     See full abstract

Blastocysts With Disproportionally High MtDNA Copy Number Can Result In Healthy Babies

Preimplantation Genetic Diagnosis International Society (PGDIS), Bangkok, Thailand 2018    See full abstract

Assessment Of Aneuploidy Concordance Between Trophectoderm And Inner Cell Mass In 100 Blastocysts By Next-Generation Sequencing

Biomarker Meeting in Personalized Reproductive Medicine, Valencia, Spain 2018     See full abstract

2017

Exploring The Chromosomal Concordance Between Trophectoderm And Inner Cell Mass Reveals A 6% ‘Biological False Negative’ Rate During Preimplantation Genetic Screening

American Society of Reproductive Medicine (ASRM), San Antonio, USA 2017    See full abstract

Quantifying Mitochondrial DNA To Predict Implantation: Myth Or Reality?

Cambridge Healthtech Institute’s Advances in Reproductive Genetic Diagnostics, Boston,  USA 2017    See full abstract

Aneuploidy Concordance Between Trophectoderm And Inner Cell Mass By Next-Generation Sequencing

Cambridge Healthtech Institute’s Advances in Reproductive Genetic Diagnostics, Boston,  USA 2017    See full abstract

Validating PGS By Probing The Karyotypic Concordance Between ICM And TE

Preimplantation Genetic Diagnosis International Society (PGDIS), Valencia, Spain 2017    See full abstract

The Effects Of Laser Manipulation On Biopsy Karyotype In PGS

Preimplantation Genetic Diagnosis International Society (PGDIS), Valencia, Spain 2017    See full abstract

Mitochondrial DNA As A Marker For Ploidy And Implantation In IVF

Fertility and Sterility Journal Club Global, January 2017

2016

Correction Factor Reveals Uniform Levels Of Mitochondrial DNA In Human Blastocysts Irrespective Of Ploidy, Age, Or Implantation Potential                      

American Society of Reproductive Medicine (ASRM), Salt Lake City, USA 2016    See full abstract

Mathematical Correction Method To Accurately Determine Mitochondrial DNA Levels Reveals Uniformity In Blastocysts

Preimplantation Genetic Diagnosis International Society (PGDIS), Bologna, Italy 2016    See full abstract

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